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Your Position: Home > M-CSF R

M-CSF R

Brief Information

Name:Colony stimulating factor 1 receptor
Target Synonym:CSFR,CD115 Antigen,FMS Proto-Oncogene,EC 2.7.10.1,CSF1R,Proto-Oncogene C-Fms,Macrophage Colony-Stimulating Factor 1 Receptor,FIM2,McDonough Feline Sarcoma Viral (V-Fms) Oncogene Homolog,CSF-1R,C-FMS,Macrophage Colony Stimulating Factor I Receptor,CD115,HDLS,EC:2.7.10.1,EC 2.7.10,CSF-1-R,CSF-1 Receptor,FMS,BANDDOS,M-CSF-R,Colony Stimulating Factor 1 Receptor
Number of Launched Drugs:8
Number of Drugs in Clinical Trials:37
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
CSR-H5543 Human Human M-CSF R Protein, His Tag (active enzyme)
CSR-H5543-structure
CSR-H5543-sds
CSR-H5255 Human Human M-CSF R / CSF1R / CD115 Protein, Mouse IgG2a Fc Tag (MALS verified)
CSR-H5255-structure
CSR-H5255-sds
CSR-R82H5 Rabbit Rabbit M-CSF R / CSF1R / CD115 Protein, His Tag
CSR-R82H5-structure
CSR-R82H5-sds
CSR-C82H3 Canine Canine M-CSF R / CSF1R / CD115 Protein, His Tag
CSR-C82H3-structure
CSR-C82H3-sds
CSR-M82E8 Mouse Biotinylated Mouse M-CSF R / CSF1R / CD115 Protein, Avitag™,His Tag
CSR-M82E8-structure
CSR-M82E8-sds
CSR-H82E0 Human Biotinylated Human M-CSF R / CSF1R / CD115 Protein, Avitag™,His Tag
CSR-H82E0-structure
CSR-H82E0-sds
CSR-C5252 Cynomolgus Cynomolgus M-CSF R / CSF1R / CD115 Protein, Fc Tag
CSR-C5252-structure
CSR-C5252-sds
CSR-C52E1 Cynomolgus Cynomolgus M-CSF R / CSF1R / CD115 Protein, His Tag
CSR-C52E1-structure
CSR-C52E1-sds
CSR-M5256 Mouse Mouse M-CSF R / CSF1R / CD115 Protein, Fc Tag, low endotoxin
CSR-M5256-structure
CSR-M5256-sds
CSR-M52E7 Mouse Mouse M-CSF R / CSF1R / CD115 Protein, His Tag
CSR-M52E7-structure
CSR-M52E7-sds
CSR-H5258 Human Human M-CSF R / CSF1R / CD115 Protein, Fc Tag, low endotoxin
CSR-H5258-structure
CSR-H5258-sds
CSR-H5228 Human Human M-CSF R / CSF1R / CD115 Protein, His Tag (MALS verified)
CSR-H5228-structure
CSR-H5228-sds
ACRO Quality

Part of Bioactivity data

CSR-H5258-SPR
M-CSF R SPR

Human M-CSF Protein, His Tag (Cat. No. MCF-H5247) captured on CM5 Chip via anti-His antibody can bind Human M-CSF R Protein, Fc Tag (Cat. No. CSR-H5258) with an affinity constant of 1.9 nM as determined in SPR assay (Biacore T200) (Routinely tested).

Protocol
CSR-H5228-SPR
M-CSF R SPR

Biotinylated Human M-CSF, His,Avitag (Cat. No. MCF-H82E6) immobilized on SA Chip can bind Human M-CSF R, His Tag (Cat. No. CSR-H5228) with an affinity constant of 0.309 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol

Synonym Name

CSF1R,C-FMS,CD115,CSFR,FIM2,FMS,M-CSFR

Background

Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR,  FIM2, FMS, and is a member of the typeⅢ subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.

Clinical and Translational Updates

Related Molecule

M-CSF

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Mirimostim P-100; CSF-HU Approved Jcr Pharmaceuticals Co Ltd Costilate, Leukoprol Japan Neutropenia Jcr Pharmaceuticals Co Ltd 1991-01-01 Neutropenia Details
Nintedanib Esylate BIBF-1120 Approved C.H. Boehringer Sohn Ag & Co. Kg Ofev, Vargatef EU systemic sclerosis-associated interstitial lung disease Boehringer Ingelheim International Gmbh 2014-10-15 Gliosarcoma; Breast Neoplasms; Sarcoma; systemic sclerosis-associated interstitial lung disease; Adenocarcinoma, Clear Cell; Peritoneal Neoplasms; Colorectal Neoplasms; Astrocytoma; Hepatic Insufficiency; Genital Neoplasms, Female; Silicosis; Prostatic Neoplasms; Carcinoma, Squamous Cell; Appendiceal Neoplasms; Fallopian Tube Neoplasms; Leukemia, Myeloid, Acute; Uterine Neoplasms; Endometrial Neoplasms; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma; Carcinoma, Endometrioid; Carcinoma, Hepatocellular; Colonic Neoplasms; Ovarian Neoplasms; Telangiectasia, Hereditary Hemorrhagic; Esophageal Neoplasms; Rejection of lung transplantation; Carcinoid Tumor; Endometrial Stromal Tumors; Carcinoma, Renal Cell; Radiation Pneumonitis; Neoplasms; Idiopathic Pulmonary Fibrosis; Solid tumours; Scleroderma, Systemic; Glioblastoma; Small Cell Lung Carcinoma; Mesothelioma; Neuroendocrine Tumors; Pulmonary Fibrosis; Lung Diseases, Interstitial; Multiple Myeloma; Asbestosis; Oligodendroglioma Details
Pexidartinib PLX-3397 Approved Daiichi Sankyo Co Ltd Turalio United States Giant Cell Tumor of Tendon Sheath Daiichi Sankyo Inc 2019-08-02 Prostatic Neoplasms; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Melanoma; Leukemia, Myeloid, Acute; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Giant Cell Tumors; Neurofibroma, Plexiform; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Neurofibrosarcoma; Sarcoma; Ovarian Neoplasms; Breast Neoplasms; Arthritis, Rheumatoid; Pancreatic Neoplasms; Glioblastoma; Neoplasms; Hodgkin Disease; Synovitis, Pigmented Villonodular; Squamous Cell Carcinoma of Head and Neck; Leukemia, Promyelocytic, Acute; Giant Cell Tumor of Tendon Sheath; Solid tumours Details
Regorafenib DAST; BAY-73-4506 Approved Bayer AG Stivarga, Resihance Mainland China Gastrointestinal Stromal Tumors Bayer Pharma Ag 2012-09-27 Leukemia, Myeloid, Acute; Sarcoma; Gastrinoma; Osteosarcoma; Sarcoma, Ewing; Colorectal Neoplasms; Peritoneal Neoplasms; Gastrointestinal Stromal Tumors; Bile Duct Neoplasms; Fallopian Tube Neoplasms; Esophageal adenocarcinoma; Adenoma; Thyroid Neoplasms; Lung Neoplasms; Thymoma; Carcinoma, Hepatocellular; Adenocarcinoma; Melanoma; Neoplasm Metastasis; Gastrointestinal Neoplasms; Somatostatinoma; Carcinoma, Islet Cell; Ovarian Neoplasms; Liver Neoplasms; Hemangiosarcoma; Esophageal Neoplasms; Stomach Neoplasms; Carcinoma, Renal Cell; Rectal Neoplasms; Carcinoid Tumor; Insulinoma; Solid tumours; Colonic Neoplasms; Neoplasms; Carcinoma, Ovarian Epithelial; Pancreatic Neoplasms; Small Cell Lung Carcinoma; Glioblastoma; Carcinoma, Transitional Cell; Carcinoma, Adenoid Cystic; Glucagonoma Details
Pacritinib SB-1518; ONX-0803 Approved Syncore Biotechnology Co Ltd, Concert VONJO United States Primary Myelofibrosis Cti Biopharma Corp 2022-02-28 Lymphoproliferative Disorders; Carcinoma, Non-Small-Cell Lung; Leukemia, Lymphocytic, Chronic, B-Cell; Thrombocythemia, Essential; Leukemia, Myelomonocytic, Juvenile; Lymphoma, T-Cell; Waldenstrom Macroglobulinemia; Thrombocytopenia; Lymphoma, T-Cell, Cutaneous; Lymphoma, Non-Hodgkin; Lymphoma; Leukemia, Myeloid, Acute; Hepatic Insufficiency; Colorectal Neoplasms; Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Primary Myelofibrosis; Coronavirus Infections; Lymphoma, Mantle-Cell; Graft vs Host Disease; Coronavirus Disease 2019 (COVID-19); Leukemia, Myelomonocytic, Chronic; Hodgkin Disease; Myeloproliferative Disorders; Myelodysplastic Syndromes; Polycythemia Vera; Lymphoma, T-Cell, Peripheral; Leukemia; Lymphoma, B-Cell Details
Surufatinib HMPL-012 Approved Hutchison Medipharma Ltd 苏泰达, SULANDA Mainland China Neuroendocrine Tumors Hutchison Medipharma Ltd 2020-12-29 Biliary Tract Neoplasms; Hematologic Neoplasms; Solid tumours; Intestinal Neoplasms; Kidney Diseases; Pancreatic neuroendocrine tumors (pNET); Neoplasms; Small Cell Lung Carcinoma; Neuroendocrine Tumors; Sarcoma; Hepatic Insufficiency; Bile Duct Neoplasms; Carcinoma, Neuroendocrine; Thyroid Neoplasms; Appendiceal Neoplasms Details
Pazopanib Hydrochloride GSK-786034; GW-786034B; SB-786034; GW-786034 Approved Glaxosmithkline Plc, Novartis Pharma Ag 维全特, Armala, Votrient, Patorma Mainland China Carcinoma, Renal Cell Novartis Pharma Schweiz Ag 2009-10-19 Peritoneal Neoplasms; Lymphoma; Uterine Neoplasms; Lung Neoplasms; Carcinoma, Small Cell; Thyroid Neoplasms; Gastrointestinal Stromal Tumors; Gliosarcoma; Carcinoma, Mucoepidermoid; Genital Neoplasms, Female; Uterine Cervical Diseases; Choriocarcinoma; Colorectal Neoplasms; Neuroblastoma; Osteosarcoma; Gastrinoma; Psoriasis; Brain Neoplasms; Urethral Neoplasms; Breast Neoplasms; Medullary thyroid cancer (MTC); von Hippel-Lindau Disease; Gastrointestinal Neoplasms; Carcinoma, Hepatocellular; Melanoma; Endodermal Sinus Tumor; Neoplasms, Germ Cell and Embryonal; Paraganglioma; Thyroid Cancer, Papillary; Neoplasm Metastasis; Uterine Cervical Neoplasms; Breast Neoplasms, Male; Prostatic Neoplasms; Macular Degeneration; Carcinoma, Non-Small-Cell Lung; Fallopian Tube Neoplasms; Leukemia, Myeloid, Acute; Glioma; Germinoma; Carcinoma, Neuroendocrine; Carcinoma, Embryonal; Carcinoma, Squamous Cell; Telangiectasia, Hereditary Hemorrhagic; Thyroid Carcinoma, Anaplastic; Neoplasms; Carcinoid Tumor; Herpes Genitalis; Pheoc Details
Sunitinib Malate PHA-290940; SU-010398; SU-11248; PNU-290940AD; PHA-290940AD; GB-102; PNU-290940; SU-011248-L-malate salt Approved Pfizer Pharmaceuticals Ltd (China) 索坦, Sutent Japan Pancreatic neuroendocrine tumors (pNET) Pfizer Inc 2006-01-26 Teratoma; Ovarian Neoplasms; Fibromatosis, Aggressive; Solid tumours; Intestinal Neoplasms; Kidney Neoplasms; Liver Neoplasms; Leiomyosarcoma; Fibrosarcoma; HIV Infections; Head and Neck Neoplasms; Lymphoma, B-Cell, Marginal Zone; Lymphoma, B-Cell; Leukemia, Myeloid, Accelerated Phase; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphoma, T-Cell, Peripheral; Ependymoma; Carcinoma, Renal Cell; Histiocytoma, Malignant Fibrous; Carcinoma; Hemangioblastoma; Carcinoma, Islet Cell; Stomach Neoplasms; Squamous Cell Carcinoma of Head and Neck; Thoracic Neoplasms; Leukemia, Hairy Cell; Abdominal Neoplasms; Esophageal Neoplasms; Polycythemia Vera; Pelvic Neoplasms; Pheochromocytoma; Glioblastoma; Neurofibromatoses; Pancreatic Neoplasms; Pancreatic neuroendocrine tumors (pNET); Salivary Gland Neoplasms; Small Cell Lung Carcinoma; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Hodgkin Disease; Lymphoma, Large B-Cell, Diffuse; Carcinoma, Ovarian Epithelial; Carcinoma, Papillary; Neoplasms; I Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
TT-00420/Atezolizumab Phase 1 Clinical Gastrointestinal Neoplasms Details
C-019199 C019199 Phase 1 Clinical Fujian Haixi New Pharmaceutical Co Ltd Solid tumours Details
PMI-04 Phase 1 Clinical Nerve Degeneration Details
AGX-0073 AGX-0073 Phase 1 Clinical Shanghai Aojian Biological Technology Co Ltd Solid tumours Details
JDB-383 JDB-383 Phase 1 Clinical Shanghai Jiabao Yaoyin Pharmaceutical Technology Co Ltd Giant Cell Tumor of Tendon Sheath Details
SYHA-1817 SYHA-1817 Phase 1 Clinical CSPC Pharmaceutical Group Ltd Biliary Tract Neoplasms; Stomach Neoplasms; Carcinoma, Squamous Cell Details
Simmitinib hydrochloride SOMCL-15-290 Phase 1 Clinical Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Solid tumours Details
Cilmostim CSF-1 Phase 3 Clinical Pfizer Pharmaceuticals Ltd (China) Presbyopia Details
Derazantinib ARQ-087.2HCl; AQ-14741087; ARQ-087; BAL-087 Phase 2 Clinical Arqule Inc Solid tumours; Biliary Tract Neoplasms; Stomach Neoplasms; Carcinoma, Transitional Cell; Cholangiocarcinoma; Urogenital Neoplasms; Carcinoma, Hepatocellular Details
APL-102 APL-102; CBT-102 Phase 1 Clinical Apollomics Inc Solid tumours Details
NMS-03592088 NMS-P088; NMS-03592088 Phase 2 Clinical Nerviano Medical Sciences Srl Leukemia, Myelomonocytic, Chronic; Leukemia, Myeloid, Acute Details
Tinengotinib TT-00420 Phase 2 Clinical TransThera Sciences (Nanjing) Inc Solid tumours; Biliary Tract Neoplasms; Stomach Neoplasms; Small Cell Lung Carcinoma; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Cholangiocarcinoma; Breast Neoplasms; Prostatic Neoplasms; Sarcoma; Thyroid Neoplasms; Gallbladder Neoplasms Details
Edicotinib JNJ-244; JNJ-527; PRV-6527; JNJ-40346527 Phase 1 Clinical Johnson & Johnson Hodgkin Disease; Arthritis, Rheumatoid; Cognitive Dysfunction; Alzheimer Disease; Leukemia, Myeloid, Acute; Crohn Disease Details
Elzovantinib TPX-0022 Phase 2 Clinical Turning Point Therapeutics Inc Solid tumours; Stomach Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Sotuletinib BLZ-945 Phase 2 Clinical Novartis Pharma Ag, Celgene Corp Solid tumours; Neoplasms; Amyotrophic Lateral Sclerosis Details
Cabiralizumab FPA-008; ONO-4687; BMS-986227 Phase 2 Clinical Five Prime Therapeutics Inc Giant Cell Tumor of Tendon Sheath; Ovarian Neoplasms; Head and Neck Neoplasms; Solid tumours; Synovitis, Pigmented Villonodular; Carcinoma, Renal Cell; Pancreatic Neoplasms; Neoplasms; Triple Negative Breast Neoplasms; Arthritis, Rheumatoid; Glioma; Carcinoma, Non-Small-Cell Lung Details
LY-3022855 IMC-CS4; LY-3022855 Phase 2 Clinical Eli Lilly And Company Solid tumours; Neoplasms; Pancreatic Neoplasms; Melanoma; Neoplasm Metastasis Details
BC-006 BC-006; BC006 Phase 1 Clinical Dragonboat Biopharmaceutical Giant Cell Tumor of Tendon Sheath; Solid tumours Details
Vimseltinib DCC-3014 Phase 3 Clinical Deciphera Giant Cell Tumor of Tendon Sheath; Synovitis, Pigmented Villonodular; Neoplasms Details
Q-702 Q-702 Phase 2 Clinical Qurient Co Ltd Solid tumours; Liver Neoplasms; Esophageal Neoplasms; Stomach Neoplasms; Neoplasms; Neoplasm Metastasis; Uterine Cervical Neoplasms Details
AMB-05X AMB-05X Phase 2 Clinical Amgen Inc Giant Cell Tumor of Tendon Sheath; Synovitis, Pigmented Villonodular; Idiopathic Pulmonary Fibrosis; Testicular Neoplasms Details
Recombinant human GM-CSF oncolytic herpes simplex virus type 2 (OH2) OH-2; BS-001; oHSV-2 Phase 2 Clinical Wuhan Binhui Biotechnology Co Ltd Solid tumours; Head and Neck Neoplasms; Esophageal Neoplasms; Pancreatic Neoplasms; Neoplasms; Liver Diseases; Central Nervous System Neoplasms; Urinary Bladder Neoplasms; Digestive System Neoplasms; Sarcoma; Breast Neoplasms; Colorectal Neoplasms; Lymphoma; Lung Neoplasms; Melanoma Details
Chiauranib CS-2164 Phase 3 Clinical Shenzhen Chipscreen Biosciences Co Ltd Ovarian Neoplasms; Solid tumours; Triple Negative Breast Neoplasms; Small Cell Lung Carcinoma; Neoplasms; Sarcoma; Lymphoma, Non-Hodgkin; Carcinoma, Hepatocellular Details
HMPL-653 HMPL-653 Phase 1 Clinical Solid tumours; Giant Cell Tumor of Tendon Sheath; Testicular Neoplasms Details
EI-1071 EI-1071; FB-1071 Phase 1 Clinical Elixiron Immunotherapeutics Inc Giant Cell Tumor of Tendon Sheath; Alzheimer Disease; Nervous System Diseases; Amyotrophic Lateral Sclerosis Details
Axatilimab SNDX-6352; UCB-6352 Phase 2 Clinical Ucb, Incyte Corp Cytokine Release Syndrome; Solid tumours; Graft vs Host Disease; Triple Negative Breast Neoplasms; Neoplasms; Respiratory Distress Syndrome, Adult; Cholangiocarcinoma; Breast Neoplasms; Coronavirus Infections; Neoplasm Metastasis Details
Emactuzumab RG-7155; 6FY6EI1X8R; RO-5509554 Phase 3 Clinical F. Hoffmann-La Roche Ltd Brenner Tumor; Ovarian Neoplasms; Head and Neck Neoplasms; Solid tumours; Carcinoma; Neoplasms; Carcinoma, Transitional Cell; Adenocarcinoma, Clear Cell; Prostatic Neoplasms; Peritoneal Neoplasms; Testicular Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Squamous Cell; Lymphoma, Non-Hodgkin; Adenocarcinoma; Carcinoma, Endometrioid Details
ABSK-021 ABSK-021 Phase 1 Clinical ABbisko Therapeutics Co Ltd Solid tumours; Giant Cell Tumor of Tendon Sheath; Neoplasms; Triple Negative Breast Neoplasms; Pancreatic Neoplasms; Graft vs Host Disease; Sarcoma; Lung Neoplasms; Amyotrophic Lateral Sclerosis Details

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